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Overview

Compound purification is one of the key activities in the Chemical and Medical industry. A typical purification process involves the following procedures;

1. Accepting crude samples
2. Dilution and duplication
3. Prepare for instruments
4. Analysis using instruments
5. Quality check
6. Store the purified compound

In any of the above procedure a rework or scrap of the sample is allowed. Apart from the above procedures various kinds of reports can be generated for the audit. Selection of software to support the compound purification is a troublesome job. Many organizations are going for developing new system, which is not only time consuming but also expensive.

Correlating the compound purification procedures with Manufacturing Execution Systems (MES) works flow.

The compound purification process resembles a manufacturing system in many ways. A manufacturing system accepts the row material's information from the Material Control System or from the ERP. Accepting the crude samples can be considered as a similar activity.

Dilution and duplication is similar to a workstation in MES. In a typical purification process dilution and duplication is conducted using various instruments or by hand.

Prepare for instruments can be considered as a data capturing screen in MES. Various instruments related information and data related to the solvent and solution and aliquot can be captured in this step.

MES is well known for controlling and monitoring instruments. Analysis using instruments is nothing but integrating the instrument protocols with the MES.

MES provides lots of quality check options including the Corrective and Preventive activities. Quality check is inbuilt in almost all available MES in the market.

MES is always having at least one module for dispatch items or stock. Storing the purified compounds can easily be handled by any MES.

Additional advantages provided by MES
MES is widely advertised as paperless. This integrated solution improves operational efficiencies while ensuring regulatory compliance and the highest levels of quality.

• Improve quality while reducing cost of quality
• Improve global operational efficiencies
• Reduce cost of regulatory compliance and minimize the impact of recalls
• Accelerate time-to-deliver purified compounds
• Implement Six Sigma and lean initiatives
• Reduce purification cycle times and crude inventory
• Improve compound receiver service
• Share real-time data on quality and crude status with the Work in Progress information.

In addition to the above MES enforces compound purification processes along the purification onramp, eliminating mistakes before they can occur. By systematically applying purification rules, organizations eliminate operator guesswork and ensure that operators adhere to consistent purification processes.

Conclusion

Manufacturing Execution System is the best fit for any compound purification management.